Authors: Florian Blachutzik Niklas Boeder Jens Wiebe Alessio Mattesini Oliver Dörr Astrid Most Timm Bauer Monique Tröbs Jens Röther Christian Schlundt Stephan Achenbach Christian Hamm Holger Nef
Publish Date: 2016/12/21
Volume: 32, Issue: 7, Pages: 781-789
Abstract
Overlapping implantation of bioresorbable vascular scaffolds is frequently necessary but its influence on vessel and scaffold structure has not been thoroughly analyzed previously The aim of this study was to analyze the acute effects of overlapping implantation on BRS as determined by optical coherence tomography OCT A total of 38 patients with de novo coronary artery stenoses who underwent OCT in the context of implantation of novolimuseluting BRS DESolve Elixir Medical Corporation Sunnyvale California USA were investigated In 15 patients overlapping implantation of two BRS was performed while 23 patients with implantation of one single BRS served as the control group OCT data were retrospectively analyzed regarding acute scaffold implantation results There were no significant differences between the overlap and control group in terms of residual inscaffold area stenosis scaffold area mean or minimal lumen area eccentricity index incomplete scaffold apposition area or malapposition While strut fracture was slightly more frequent in BRS with overlap its incidence was low overall In patients with overlapping BRS overlap segments did not display smaller lumen areas than segments without overlap mean lumen area overlap 816 ± 297 mm2 vs no overlap 770 ± 255 mm2 p = 071 minimal lumen area overlap 683 ± 271 mm2 vs no overlap 617 ± 258 mm2 p = 037 Acute mechanical performance of novolimuseluting BRS is not impaired by overlapping implantation It can be assumed that vessel expansion compensates for the double scaffold layer in the overlap area resulting in a similar lumen area in overlap areas and in those with a single strut layer
Keywords: