Authors: Andrzej Wykretowicz Lidia Metzler Agata Milewska Marek Balinski Agnieszka Rutkowska Karolina Adamska Tomasz Krauze Przemysław Guzik Mieczysław Dziarmaga Henryk Wysocki
Publish Date: 2008/03/05
Volume: 23, Issue: 1, Pages: 16-19
Abstract
Several hemodynamic indices measured invasively in the ascending aorta during routine angiography are related to the presence and severity of coronary atherosclerosis Radial artery tonometry when combined with a validated transfer function offers the possibility of noninvasive assessment of central arterial pressure We aim to evaluate the association between noninvasive indices of aortic or radial pressure waveforms and the presence of a significant coronary stenosis Patients who underwent elective coronary angiography were studied 110 men 91 women mean age 53 ± 09 years Noninvasive measurement of their central hemodynamics was performed by analysis of the aortic pressure waveform derived from the radial artery An increase in aortic fractional pulse pressure was associated with coronary artery narrowing or previous myocardial infarction After multivariate adjustment the odds ratio and confidence intervals CI of having a significant coronary aortic stenosis was 172 95 CI 11–27 and of previous myocardial infarction 16 95 CI 11–22 An increase in noninvasively assessed aortic fractional pulse pressure but not of the peripheral index is significantly associated with the presence of coronary artery disease
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