Authors: Yusuke Okamoto Shuichi Fujita Hideaki Morita Shun Kizawa Takahide Ito Kazushi Sakane Koichi Sohmiya Masaaki Hoshiga Nobukazu Ishizaka
Publish Date: 2014/09/16
Volume: 31, Issue: 1, Pages: 66-73
Abstract
Besides regulating calciumphosphate metabolism fibroblast growth factor23 FGF23 and Klotho have been proposed to have other roles in heart and vasculature For example FGF23 has been associated with cardiac hypertrophy and reduced left ventricular ejection fraction among patients with chronic kidney disease and cardiovascular disorders The purpose of the study was to investigate whether serum FGF23 and αKlotho concentrations are associated with cardiac diastolic dysfunction and related parameters among cardiac patients with preserved left ventricular ejection fraction The current study enrolled 269 patients 69 women 200 men who were admitted to our cardiology department between October 2012 and January 2014 and had a left ventricular ejection fraction of 50 Cardiac diastolic function was assessed by blood flow and tissue Doppler velocities plasma Btype natriuretic peptide BNP concentration and cardiac hypertrophy After adjusting for sex and age logistic regression analysis showed that logαKlotho but not logFGF23 was significantly associated with diastolic dysfunction After further adjustment for renal function blood hemoglobin and serum albumin levels the negative association between logαKlotho and diastolic dysfunction retained statistical significance with an odds ratio of 050 95 confidence interval 031–081 P = 0005 per 1 standard deviation Among patients with preserved LVEF serum αKlotho concentrations were negatively associated with diastolic dysfunction Whether modulation of serum levels αKlotho will ameliorate cardiac diastolic function among patients with this disorder awaits further investigation
Keywords: