Authors: Yusuke Jo Toshihisa Anzai Koji Ueno Hidehiro Kaneko Takashi Kohno Yasuo Sugano Yuichiro Maekawa Tsutomu Yoshikawa Hideyuki Shimizu Ryohei Yozu Satoshi Ogawa
Publish Date: 2010/10/09
Volume: 25, Issue: 6, Pages: 509-514
Abstract
ddimer measurement is a useful complementary initial diagnostic marker in patients with acute aortic dissection AAD However it has not been clarified whether serial measurements of ddimer are useful during inhospital management of Stanford type B AAD We studied 30 patients who were admitted with diagnosis of Stanford type B AAD and treated conservatively ddimer was serially measured on admission and then every 5 days during hospitalization Patients were divided into two groups according to the presence or absence of reelevation of ddimer during hospitalization in which ddimer transition were biphasic and latter peak 100 μg/ml Reelevation of ddimer was observed in 17 patients There were no differences in atherosclerotic risk factors blood pressure on admission ddimer level on admission extent of AAD and false lumen patency Patients with reelevation of ddimer showed higher incidence of redissection and/or venous thromboembolism VTE Peak ddimer level in patients with redissection and/or VTE was significantly higher than that without these complications p = 0005 In conclusion serial measurements of ddimer are useful for early detection of redissection or VTE in patients with Stanford type B AAD which may contribute to the prevention of disastrous consequences such as pulmonary embolism and extension of AAD
Keywords: