Authors: Kan Dong JunHua Ge ShuLian Gu Shan Li WeiGuo Zhu FangYan Fan JianHua Zhu
Publish Date: 2011/01/08
Volume: 26, Issue: 6, Pages: 637-645
Abstract
The importance of the interaction between natural killer NK cells and dendritic cells DCs in the expansion of antiviral and antitumor immune responses is well documented however limited information on NK/DC interaction during atherosclerosis is available Inflammation plays an important role in the development of atherosclerosis and oxidized lowdensity lipoprotein oxLDL is believed to play a critical role in the development and progression of atherosclerosis In this study we developed a NK/DC coculture system to examine the role of oxLDL in modulating the interaction of mice NK cells and DCs Fresh NK cells were cocultured with DCs in the absence or presence of oxLDL We examined the cytokines released during the interaction This report provides the first evidence of an enhancement effect by oxLDL on the NK/DC crosstalk Notably we found that oxLDL significantly promoted the interaction of NK cells and DCs via CD482B4 contactdependent mechanisms These findings highlight the importance of NK/DCs crosstalk in atherosclerosis and provide new information about the possible mechanisms of atherosclerosis
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