Authors: Yoshiteru Maeda Atsushi Suzuki Junnichi Ishii Sahoko SekiguchiUeda Megumi Shibata Yasumasa Yoshino Shogo Asano Nobuki Hayakawa Kazuhiro Nakamura Yasukazu Akiyama Fumihiko Kitagawa Toshiaki Sakuishi Takashi Fujita Shuji Hashimoto Yukio Ozaki Mitsuyasu Itoh
Publish Date: 2014/03/14
Volume: 30, Issue: 3, Pages: 362-368
Abstract
Urinary livertype fatty acidbinding protein LFABP reflects the degree of stress in proximal tubules of the kidney We examined the level of LFABP in type2 diabetes mellitus T2DM patients with chronic kidney disease CKD stage G1 and G2 and its relationship with cardiac markers and electrocardiographic ECG abnormalities T2DM patients whose estimated glomerular filtration rate eGFR was ≥60 mL/min/173 m2 were recruited n = 276 165 males mean age 64 years The median level of urinary LFABP was 66 μg/gCr Urinary LFABP showed significant correlation with urinary albumintocreatinine ratio ACR r = 051 p 00001 Median 25th–75th percentile eGFR was 82 72–95 mL/min/173 m2 We divided patients into four subgroups group 1 LFABP ≤84 μg/gCr and ACR ≤30 mg/gCr group 2 LFABP ≤84 μg/gCr and ACR 30 mg/gCr group 3 LFABP 84 μg/gCr and ACR ≤30 mg/gCr group 4 LFABP 84 μg/gCr and ACR 30 mg/gCr Compared with group 1 group 4 was significantly higher in systolic blood pressure and eGFR using standardized serum cystatin C highsensitivity troponin T and Nterminal probrain natriuretic peptide NTproBNP Group 4 had significantly higher level of NTproBNP than group 3 Groups 2 3 and 4 showed more ECG abnormalities than group 1 These findings suggest that simultaneous measurement of urinary LFABP and ACR should be useful to assess cardiovascular damage reflecting on the elevation of cardiac markers and ECG abnormalities in T2DM with CKD G1 and G2
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