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Title of Journal: International Orthopaedics SICOT

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Abbravation: International Orthopaedics

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Springer-Verlag

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DOI

10.1007/s11009-011-9258-3

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1432-5195

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Preparation antibacterial properties and biocompa

Authors: LiangHua Tang ChangHong Zhao Yan Xiong AiMin Wang
Publish Date: 2009/05/24
Volume: 34, Issue: 5, Pages: 755-759
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Abstract

In the clinic implantassociated infections are the chief risk facing orthopaedics and traumatology departments VancomycinpolyDLlactic acid PDLLA loaded plates were prepared by using solvent casting technology The bacteriostatic activity to Staphylococcus aureus was evaluated in vitro The biocompatibility of the plates was investigated by acute systemic toxicity test haemolytic test cytotoxicity test etc The in vitro inhibition test of Staphylococcus aureus showed that the plates had an inhibitory effect on Staphylococcus aureus There was no toxicity for the vancomycinPDLLA loaded plates There was a good biocompatibility for the vancomycinPDLLA loaded plates These findings indicate that the plate maybe used to prevent or cure infectionWe gratefully acknowledge the contributions of Daping Hospital Third Military Medical University Chongqing China and the National 985 Research Center of Bioinspired Material Science Engineering for providing the laboratory as well as various experimental materials This study was supported by the Foundation for the Key Science Technology Research Project of Chongqing The authors did not receive any payment or benefits from any other research fund foundation educational institution or other nonprofit organizations No benefits in any form have been received or will be received from a commercial party related directly or indirectly to the subject of this article

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