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Title of Journal: International Orthopaedics SICOT

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Abbravation: International Orthopaedics

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Springer Berlin Heidelberg

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1432-5195

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Tumour response of osteosarcoma to neoadjuvant che

Authors: Christoph J Laux Gundula Berzaczy Michael Weber Susanna Lang Martin Dominkus Reinhard Windhager IrisMelanie NöbauerHuhmann Philipp T Funovics
Publish Date: 2014/11/30
Volume: 39, Issue: 1, Pages: 97-104
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Abstract

This study evaluated the feasibility of computed magnetic resonance imaging MRI volumetry in conventional osteosarcomas Secondly we investigated whether computed volumetry provides new prognostic indicators for histological response of osteosarcomas after neoadjuvant chemotherapyIn a retrospective cohort study data from the Vienna Bone Tumour Registry was used MR images from 14 patients malefemale = 18 mean age 19 years were analysed prior to and after neoadjuvant chemotherapy according to current therapy regimens Histological response to chemotherapy was graded according to the SalzerKuntschik classification Computed volumetry was performed for the intraosseous part as well as the softtissue component and the tumour as a wholeIn a setting of appropriate radiological equipment the method has been considered to be well implementable into clinical routine The mean tumour volume prior to chemotherapy was 321 ±351 ml In good responders n = 6 overall tumour volume decreased by 47  p = 0345 whereas poor responders n = 8 showed a 19  decrease p = 0128 Neoadjuvant multidrug therapy remarkably changed the tumour composition This is seen in a decrease of the mean ratio of softtissue to intraosseous tumour volume from 867 in poor responders and 115 in good responders to 126 and 045 p = 0065 respectively Interestingly the bony compartment of good responders showed a volume increase during neoadjuvant chemotherapy p = 0073 However we did not find prognostic markers for histological tumour response to preoperative chemotherapy

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