Paper Search Console

Home Search Page About Contact

Journal Title

Title of Journal: International Orthopaedics SICOT

Search In Journal Title:

Abbravation: International Orthopaedics

Search In Journal Abbravation:

Publisher

Springer-Verlag

Search In Publisher:

ISSN

1432-5195

Search In ISSN:
Search In Title Of Papers:

Vascular endothelial growth factor gene silencing

Authors: Wei Zhang Xiaochun Peng Tao Cheng Xianlong Zhang
Publish Date: 2011/04/08
Volume: 35, Issue: 12, Pages: 1883-1888
PDF Link

Abstract

Aseptic loosening is the most common complication of total joint replacement which most likely results from an inflammatory response to wear debris shed from the implant In this study we aimed to investigate whether the lentivirusmediated microRNA miRNA targeting vascular endothelial growth factor VEGF could inhibit wear debrisinduced inflammation in a murine modelTitanium alloy particles were introduced into established air pouches on BALB/c mice followed by implantation of calvarial bone from a syngeneic mouse After treatment by locally delivered lentivirusmediated VEGF miRNA inflammatory tissues were collected for histology and molecular analysisWe found that 1 locally delivered miRNA inhibited titanium alloy particleinduced tissue inflammation including the diminished pouch membrane thickness and reduced inflammatory cellular infiltration and that 2 locally delivered miRNA inhibited expressions of the inflammatory cytokines VEGF tumour necrosis factorα TNFα interleukin1β IL1β and receptor activator of nuclear factor kappa B ligand RANKL

Keywords:

References

.
Search In Abstract Of Papers:
Other Papers In This Journal:
  1. The reliability of four widely used patellar height ratios
  2. The use of an eccentric glenosphere compared with a concentric glenosphere in reverse total shoulder arthroplasty: two-year minimum follow-up results
  3. Effect of surgical delay on outcome in hip fracture patients: a retrospective multivariate analysis of 192 patients
  4. Primary cementless hip arthroplasty as a potential risk factor for non-union after long-stem revision arthroplasty in periprosthetic femoral fractures
  5. Preparation, antibacterial properties and biocompatibility studies on vancomycin-poly(D,L)-lactic loaded plates
  6. Has the management of shoulder dislocation changed over time?
  7. Does an increase in modularity improve the outcomes of total shoulder replacement? Comparison across design generations
  8. Intertrochanteric osteotomy in young adults for sequelae of Legg-Calvé-Perthes’ disease—a long term follow-up
  9. Posterior lumbar interbody fusion versus posterolateral fusion in spondylolisthesis: a prospective controlled study in the Han nationality
  10. Antibiotic-loaded bone cement spacers in two-stage management of infected total knee arthroplasty
  11. Skeletal tissue regeneration: where can hydrogels play a role?
  12. Gait characteristics before hardware removal in patients operated upon for tibial plateau fractures
  13. Zoledronate reduces unwanted bone resorption in intercalary bone allografts
  14. Anchor suture fixation of distal pole fractures of patella: twenty seven cases and comparison to partial patellectomy
  15. A 5 to 8 year follow-up study of the Rotaglide mobile bearing total knee arthroplasty
  16. Wide resection of sacral chordoma via a posterior approach
  17. The influence of stem offset and neck shaft angles on the range of motion in total hip arthroplasty
  18. Marshall R. Urist and the discovery of bone morphogenetic proteins
  19. Fondaparinux prevents venous thromboembolism after joint replacement surgery in Japanese patients
  20. Complications of definitive open reduction and internal fixation of pilon fractures of the distal tibia
  21. Tumour response of osteosarcoma to neoadjuvant chemotherapy evaluated by magnetic resonance imaging as prognostic factor for outcome
  22. Role of MRI in detecting early physeal changes due to acute osteoarticular infection around the knee joint: a pilot study
  23. Lengthening of short bones by distraction osteogenesis—results and complications
  24. Validity of published outcome data concerning Anatomic Graduated Component total knee arthroplasty: a structured literature review including arthroplasty register data
  25. Tibial lengthening over an intramedullary nail in patients with short stature or leg-length discrepancy: a comparative study
  26. Sacroiliac joint tuberculosis
  27. Delayed union of multifragmentary diaphyseal fractures after bridge-plate fixation
  28. Clinical and biological assessment of cemented titanium femoral stems: an 11-year experience
  29. Association of oestrogen receptor gene polymorphism with the long-term results of rotational acetabular osteotomy
  30. Surgical treatment of undisplaced femoral neck fractures in the elderly
  31. Modified sacrospinalis muscle pedicle bone graft for fusion of isthmic spondylolisthesis
  32. Design and application of Nickel-Titanium olecranon memory connector in treatment of olecranon fractures: a prospective randomized controlled trial
  33. Surgical treatment for young adult hip dysplasia: joint-preserving options
  34. Anatomical principles for minimally invasive reconstruction of the acromioclavicular joint with anchors
  35. The gait of patients with one resurfacing and one replacement hip: a single blinded controlled study
  36. Integrated care pathways in lower-limb arthroplasty: are they effective in reducing length of hospital stay?
  37. Percutaneous reduction and leverage fixation using K-wires in paediatric angulated radial neck fractures
  38. Distal tibia fractures: management and complications of 101 cases
  39. Surgical fixation of sternal fractures: locked plate fixation by low-profile titanium plates—surgical safety through depth limited drilling
  40. Bovine xenograft locking Puddu plate versus tricalcium phosphate spacer non-locking Puddu plate in opening-wedge high tibial osteotomy: a prospective double-cohort study
  41. Are abductor muscle quality and previous revision surgery predictors of constrained liner failure in hip arthroplasty?
  42. Mono versus polyaxial locking plates in distal femur fractures: a prospective randomized multicentre clinical trial
  43. Identification of prognostic factors for the nonoperative treatment of stiff shoulder
  44. Single-row versus double-row arthroscopic repair in the treatment of rotator cuff tears: a prospective randomized clinical study
  45. Post-discectomy syndrome treated with lumbar interbody fusion
  46. In-out-in technique for acetabular fractures: is it really good?
  47. Impaction bone grafting and a cemented cup after acetabular fracture
  48. Spinal deformity after multilevel osteoplastic laminotomy
  49. Comparison of tibial rotation in fixed and mobile bearing total knee arthroplasty using computer navigation
  50. Management of periprosthetic acetabular fractures in elderly patients—a minimally invasive approach
  51. Modular megaprosthesis for distal femoral tumors
  52. Proximal humerus reconstruction after tumour resection: biological versus endoprosthetic reconstruction
  53. Factors predicting the failure of Bernese periacetabular osteotomy: a meta-regression analysis
  54. Acetabular rim lesions: arthroscopic assessment and clinical relevance
  55. Predictors of disease-specific quality of life after arthroscopic rotator cuff repair
  56. Incidence and preventability of adverse events in an orthopaedic unit: a prospective analysis of four thousand, nine hundred and six admissions
  57. Osseointegration in hip prostheses: experimental study in sheep
  58. Analysis of synovial fluid in knee joint of osteoarthritis:5 proteome patterns of joint inflammation based on matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
  59. Radiographic correlation of symptomatic and asymptomatic flexible flatfoot in young male adults
  60. One-stage combined anterior-posterior approach treatment of multiple cervicothoracic spinal tuberculosis with kyphosis
  61. A five to seven year follow-up comparing computer-assisted vs freehand TKR with regard to clinical parameters
  62. Pre-operative scoring system to determine the surgical strategy for periprosthetic hip infection
  63. GRADE outcomes or studies: how to use the GRADE approach correctly?
  64. Histopathology of aseptic necrosis of the femoral head in sickle cell disease
  65. Shoulder arthrodesis with a reconstruction plate
  66. Intra-articular injection of tranexamic acid reduces not only blood loss but also knee joint swelling after total knee arthroplasty
  67. Regulatory authorities and orthopaedic clinical trials on expanded mesenchymal stem cells
  68. Regulatory authorities and orthopaedic clinical trials on expanded mesenchymal stem cells
  69. Survivorship and clinical outcome of Birmingham hip resurfacing: a minimum ten years’ follow-up
  70. Comment on Korsten et al.: Operative or conservative treatment in patients with Rockwood type III acromioclavicular dislocation: a systematic review and update of current literature
  71. Comment on Korsten et al.: Operative or conservative treatment in patients with Rockwood type III acromioclavicular dislocation: a systematic review and update of current literature
  72. Outcomes of radical debridement versus no debridement for the treatment of thoracic and lumbar spinal tuberculosis
  73. Vascularised iliac graft as a method of acetabular augmentation in subluxed hip in adolescents
  74. Un cas de mélorhéostose
  75. Primary bipolar hemiprosthesis for unstable intertrochanteric fractures
Search Result: