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Title of Journal: Surg Today

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Abbravation: Surgery Today

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Springer-Verlag

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DOI

10.1016/j.annder.2011.09.161

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1436-2813

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Role of thymidylate synthase and dihydropyrimidine

Authors: Yuji Morine Mitsuo Shimada Tohru Utsunomiya Satoru Imura Tetsuya Ikemoto Jun Hanaka Mami Kanamoto Nobuhiro Kurita Hidenori Miyake
Publish Date: 2011/12/06
Volume: 42, Issue: 2, Pages: 135-140
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Abstract

Thymidylate synthase TS and dihydropyrimidine dehydrogenase DPD are important enzymes in the metabolism of 5fluorouracil and possible predictive markers We conducted this study to clarify if TS and DPD gene expressions are a prognostic indicator for intrahepatic cholangiocarcinoma IHCCThe subjects of this study were 21 patients with IHCC who had undergone surgical resection Intratumoral TS and DPD mRNA expressions were examined using the Danenberg tumor profile method and classified into two groups according to the median value of each We then compared the clinicopathological variables including prognosis between the high and low expression groupsLow DPD expression was correlated with macroscopic type namely massforming + infiltrative P = 008 Postoperative survival rates in the low DPD expression group were significantly lower than those in the high DPD expression group Multivariate analysis revealed macroscopic type to be an independent prognostic factor whereas TS mRNA expression did not correlate with any clinicopathological variables including prognosis

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