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Title of Journal: Surg Today

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Abbravation: Surgery Today

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Springer Japan

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10.1016/0002-9610(78)90231-3

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1436-2813

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Comparison of the efficacy of chlorhexidine glucon

Authors: Anirudh Srinivas Lileswar Kaman Prithivi Raj Vikas Gautam Divya Dahiya Gurpreet Singh Rajinder Singh Bikash Medhi
Publish Date: 2014/11/09
Volume: 45, Issue: 11, Pages: 1378-1384
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Abstract

This was a prospective randomized controlled trial conducted on patients undergoing cleancontaminated upper abdominal surgeries A total of 351 patients 18–70 years old were randomized into two groups chlorhexidine and povidone iodine skin preparation before surgeryThe incidence of SSIs in the chlorhexidine group was 108  in comparison to 179  in the povidone iodine group The odds ratio was 06 in favor of chlorhexidine use but the results were not statistically significant P = 006 In the first postoperative week SSIs developed in 7  of patients in the chlorhexidine group and 141  in the povidone iodine group P = 003 and in the second postoperative week SSIs were present in 41  of the patients in the chlorhexidine group and 44  in the povidone iodine group which was not statistically significant P = 088The incidence of SSIs after cleancontaminated upper abdominal surgeries was lower with the use of chlorhexidine skin preparation than with povidone iodine preparation although the results were not statistically significant However the odds ratio between the two groups favored the use of chlorhexidine over povidone iodine for preventing SSIs

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