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Title of Journal: Surg Today

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Abbravation: Surgery Today

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Springer Japan

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10.1007/s10551-010-0508-z

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1436-2813

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Role of the intraluminal contents and the continui

Authors: Daisuke Kikuchi Chikashi Shibata Hirofumi Imoto Soutoku Someya Tomohiro Miyachi Koh Miura Takeshi Naitoh Michiaki Unno
Publish Date: 2013/01/30
Volume: 44, Issue: 1, Pages: 152-159
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Abstract

Five beagle dogs were equipped with three strain gauge force transducers throughout the colon The colonic contractile activity in response to intracolonic capsaicin was studied in intact dogs dogs after colonic cleansing and dogs with transection/reanastomosis T/R between the proximal and middle colon The effects of intravenous yohimbine a α2 adrenergic antagonist on the colonic motility and defecation were also studied in the same modelsIn intact dogs capsaicin 10 mg and yohimbine 2 mg/kg immediately induced contractions throughout the colon with defecation occurring in all experiments In dogs after colonic cleansing and T/R the capsaicin 10 mginduced enhancement of colonic motility was decreased in the middle and distal colon and capsaicininduced defecation was observed in 0–20  of experiments p  005 compared to intact dogs The effect of yohimbine 2 mg/kg in inducing colonic contractions was unaltered after colonic cleansing and T/R in contrast yohimbineinduced defecation was not observed after colonic cleansing but was unchanged after T/R

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