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Title of Journal: Food Sci Biotechnol

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Abbravation: Food Science and Biotechnology

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Springer Netherlands

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DOI

10.1016/0300-9629(74)90048-6

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ISSN

2092-6456

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Antiinflammatory activity of ethanolic extract of

Authors: MinJi Kim KothBongWooRi Kim DaHyun Jeong DongHyun Ahn
Publish Date: 2013/08/31
Volume: 22, Issue: 4, Pages: 1113-1120
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Abstract

Aim of the study is to evaluate the antiinflammatory effects of ethanolic extract of the marine brown alga Sargassum sagamianum collected from Yeonhwari coast of Korea Ethanolic extract of S sagamianum SAE extract inhibited expression of nitric oxide NO and cytokines IL6 IL1β and TNFα as well as inducible nitric oxide synthase iNOS and cyclooxygenase COX2 in lipopolysaccharide LPSinduced RAW 2647 cells without affecting cell viability In addition the expression of nuclear factor NFκB p65 was suppressed by SAE extract Furthermore the rate of formation of edema in the mouse ear was reduced by 46 at the highest dose tested 250 mg/kg compared to that in the control This study suggests that SAE extract exerts potent inhibitory effects on LPSinduced expression of inflammatory mediators such as NO iNOS COX2 and cytokines in macrophages through suppression of the NFκB p65 pathway SAE extract might have potential clinical applications as an antiinflammatory agent

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