Authors: JungMin Hwang KiChoon Choi SungJun Bang YoungOk Son BeomTae Kim DongHern Kim Gi Jun Choi Da Hye Kim Xianglin Shi JeongChae Lee
Publish Date: 2013/02/28
Volume: 22, Issue: 1, Pages: 265-272
Abstract
Corn sorghum barley Italian ryegrass IRG and alfalfa have long been used in human and/or animal diets While their nutritional information is widely available their potentials for antioxidation antiinflammation and antitumor are barely explored In the present study several serial extracts were prepared from 70 methanol extracts of these forage crops and their bioactive potentials were investigated using cellfree and cellmediated experimental systems Chloroform extracts in this study generally showed stronger activity to scavenge hydroxyl radicals and superoxide anions than butanol or water extracts IRG and sorghum chloroform extracts especially almost completely suppressed the lipopolysaccharidemediated production of nitric oxide tumornecrosis factorα and interleukin6 These extracts also inhibited dramatically the viability and DNA synthesis of human skin dermatofibrosarcoma cells without a toxic effect on primary cultured control cells These beneficial effects appeared to be associated with the amount of flavonoids contained in the extracts
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