Authors: Rosa Martha Perez Gutierrez
Publish Date: 2016/02/29
Volume: 25, Issue: 1, Pages: 229-239
Abstract
Bioactivityguided fractionation of methanol extracts from leaves of Piper auritum produced four triterpenoid saponin compounds 14 Structures were established based on interpretation of mass spectrometry MS nuclear magnetic resonance NMR data 21pmethoxycinnamoylolean12ene28oic cid3OαLarabinopyranosyl1→2βDglucopyranoside 1 and olean12ene28 methyl ester3OαLarabinofuranosyl1→2βDglucopyranoside 2 were orally administered to diabetic mice at dosage of 10 mg/kg of body weight per day for 30 days and resultant biochemical parameters were studied Both compounds significantly p005 decreased serum glucose total cholesterol and triglyceride levels compared with controls Low density lipoprotein and high density lipoprotein cholesterol levels were ameliorated The effects of lipid peroxidation and oxidative stress in the liver pancreas and kidney were reversed with reductions insulin resistance and stimulation of insulin production βGlucosidase activities were studied in vitro Compounds 1 and 2 can be used to improve glucose and lipid metabolism and to reduce the imbalance between generation of reactive oxygen species and scavenging enzyme activities for prevention of diabetic complications
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