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Title of Journal: J Abnorm Child Psychol

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Abbravation: Journal of Abnormal Child Psychology

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Springer US

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DOI

10.1002/ajim.4700250215

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1573-2835

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A DoseRanging Study of Behavioral and Pharmacolog

Authors: William E Pelham Lisa BurrowsMacLean Elizabeth M Gnagy Gregory A Fabiano Erika K Coles Brian T Wymbs Anil Chacko Kathryn S Walker Frances Wymbs Allison Garefino Martin T Hoffman James G Waxmonsky Daniel A Waschbusch
Publish Date: 2014/01/16
Volume: 42, Issue: 6, Pages: 1019-1031
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Abstract

Placebo and three doses of methylphenidate MPH were crossed with 3 levels of behavioral modification no behavioral modification NBM lowintensity behavioral modification LBM and highintensity behavior modification HBM in the context of a summer treatment program STP Participants were 48 children with ADHD aged 5–12 Behavior was examined in a variety of social settings sports activities art class lunch that are typical of elementary school neighborhood and afterschool settings Children received each behavioral condition for 3 weeks order counterbalanced across groups Children concurrently received in random order placebo 015 mg/kg/dose 03 mg/kg/dose or 06 mg/kg/dose MPH 3 times daily with dose manipulated on a daily basis in random order for each child Both behavioral and medication treatments produced highly significant and positive effects on children’s behavior The treatment modalities also interacted significantly Whereas there was a linear dose–response curve for medication in NBM the dose–response curves flattened considerably in LBM and HBM Behavior modification produced effects as large as moderate doses and on some measures high doses of medication These results replicate and extend to socialrecreational settings previously reported results in a classroom setting from the same sample Fabiano et al School Psychology Review 36 195–216 2007 Results illustrate the importance of taking dosage/intensity into account when evaluating combined treatments there were no benefits of combined treatments when the dosage of either treatment was high but combination of the lowdose treatments produced substantial incremental improvement over unimodal treatmentThis research was funded by a grant from the National Institute of Mental Health MH62946 Dr Pelham was also supported in part by grants from the National Institute of Mental Health MH092466 MH53554 MH065899 MH62988 the Institute of Education Sciences R37A120169 LO30000665A R324B06045 the National Institute of Alcohol Abuse and Alcoholism AA11873 the National Institute on Drug Abuse DA12414 DA12986 and the National Institute of Child Health and Human Development HD040935This study was funded by a grant from the National Institute of Mental Health MH62946 During the conduct of this study and preparation of this report Dr Pelham was also funded by grants from the National Institutes of Health MH62946 MH69614 MH53554 MH69434 MH65899 MH78051MH062946 NS39087 AA11873 DA12414 HD42080 and the Institute of Education Sciences L03000665A Dr Fabiano was supported in part by a Ruth S Kirschstein National Research Service Award Predoctoral Fellowship 1F31MH06424301A1 and by the Department of Education Institute of Education Sciences R324J06024 R324B06045


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Other Papers In This Journal:

  1. Expression of Anger in Depressed Adolescents: The Role of the Family Environment
  2. Links Between Antisocial Behavior and Depressed Mood: The Role of Life Events and Attributional Style
  3. Latent Class Analysis of Antisocial Behavior: Interaction of Serotonin Transporter Genotype and Maltreatment
  4. The Pictorial Fire Stroop: A Measure of Processing Bias for Fire-Related Stimuli
  5. Emotion Dysregulation as a Mechanism Linking Stress Exposure to Adolescent Aggressive Behavior
  6. Father Participation in Child Psychopathology Research
  7. Executive Functioning Characteristics Associated with ADHD Comorbidity in Adolescents with Disruptive Behavior Disorders
  8. Peer Experiences in Short-Term Residential Treatment: Individual and Group-Moderated Prediction of Behavioral Responses to Peers and Adults
  9. Erratum to: Do Childhood Externalizing Disorders Predict Adult Depression? A Meta-Analysis
  10. Variation in Parasympathetic Dysregulation Moderates Short-term Memory Problems in Childhood Attention-Deficit/Hyperactivity Disorder
  11. Peer Rejection and Friendships in Children with Attention-Deficit/Hyperactivity Disorder: Contributions to Long-Term Outcomes
  12. ODD Symptom Network during Preschool
  13. Attentional Biases for Emotional Faces in Young Children of Mothers with Chronic or Recurrent Depression
  14. Co-Rumination Exacerbates Stress Generation among Adolescents with Depressive Symptoms
  15. Implicit and Explicit Self-Esteem Discrepancies, Victimization and the Development of Late Childhood Internalizing Problems
  16. Respiratory Sinus Arrhythmia Moderates the Relation between Parent-Adolescent Relationship Quality and Adolescents’ Social Adjustment
  17. Executive Functioning as a Mediator of Conduct Problems Prevention in Children of Homeless Families Residing in Temporary Supportive Housing: A Parallel Process Latent Growth Modeling Approach
  18. Positive Affect in Infant Siblings of Children Diagnosed with Autism Spectrum Disorder
  19. Examining Early Behavioral Persistence as a Dynamic Process: Correlates and Consequences Spanning Ages 3–10 Years
  20. The Academic Experience of Male High School Students with ADHD
  21. Dynamic Associations between Maternal Depressive Symptoms and Adolescents’ Depressive and Externalizing Symptoms
  22. The Association Between Observed Parental Emotion Socialization and Adolescent Self-Medication
  23. Maternal Prenatal Psychological Distress and Preschool Cognitive Functioning: the Protective Role of Positive Parental Engagement

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