Left Ventricular Dysfunction Pulmonary Hypertensi

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Publish Date: 2001

Volume: 05, Issue: 02, Pages: 057-062

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Abstract

The purpose of this study was to determine the frequency of central and obstructive sleep apnea in adult patients who have echocardiographic evidence of left ventricular dysfunction and pulmonary hypertension Subjects with left ventricular dysfunction pulmonary hypertension pulmonary artery systolic pressure 30 mm Hg and no lung disease were evaluated for risk factors associated with pulmonary hypertension Of eight eligible adults six completed the study Subjects were from suburban and inner city family practices Spirometric assessment pulse oximetry on room air rheumatologic evaluation polysomnography and additional history were taken All six subjects had sleep apnea apneaplushypopnea index or AHI ≥20 obstructive central or mixed All were obese and almost all the subjects had a restrictive pattern on spirometry which is consistent with obesity All had a pulmonary artery systolic blood pressure of 35 mm Hg or greater None had daytime hypoxemia or collagen vascular disease and none had ever used appetite suppressants This study found a strong association between pulmonary hypertension and obstructive or central sleep apnea in obese patients with congestive heart failure CHF We propose that a pulmonary artery systolic pressure of 35 mm Hg or greater in ambulatory patients with CHF may signify an increased risk of sleep apnea

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