Authors: J Roemmler B Gutt R Fischer S Vay A Wiesmeth M Bidlingmaier J Schopohl M Angstwurm
Publish Date: 2012/01/13
Volume: 16, Issue: 4, Pages: 1247-1253
Abstract
We performed polysomnographies in 52 patients with acromegaly 25 m 27 f age 51 years range 1982 years Patients were defined having SA if they had more than five apnoeas or hypopnoeas per hour respiratory disturbance index = RDI The type of SA was divided into obstructive OSA central CSA or mixed OSA+CSA Seventeen patients had newly diagnosed disease and 18 patients were treated with somatostatin analoguesTwentythree patients had controlled disease activity mean GH levels 1 μg/l during a 3h profile and normalised IGF1 levels Twelve had active acromegaly despite medical treatment Thirty patients 58 had SA Twentyfive of those had OSA three had CSA and two had mixed Of the patients with active disease 66 had SA compared to 48 in the cured group Significantly more patients with hypertension n = 18 than without hypertension n = 12 p = 0041 had SA Basal glucose was not significantly different between patients with 100 mg/dl range 75–207 mg/dl and without SA 92 mg/dl range 74–120 mg/dl but HbA1c was significantly higher in patients with SA 59 49–90 vs 54 43–61 p = 0001 A positive correlation between RDI and BMI p = 004 RDI and age p = 0013 and RDI and disease activity p = 0014 was seen No major correlation could be found between RDI and the duration of disease activity nor between RDI and GH levels
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