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Title of Journal: Sleep Breath

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Abbravation: Sleep and Breathing

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Copyright © 2001 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

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DOI

10.1016/0022-1910(76)90255-9

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ISSN

1522-1709

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Employee/Employer Interactions and Responsibilitie

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Publish Date: 2001
Volume: 05, Issue: 03, Pages: 153-162
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Abstract

Although genetic diseases are not communicable in the ordinary sense the genetic profile of some individuals can influence them to act in ways that can cause direct harm to third parties Significant scholarly work is beginning to address ethical legal and social issues raised by a persons genetic susceptibility to engage in sociopathic and other forms of intentional or criminal behavior1 Another major type of direct harm to third parties that may be causally related to an individuals genetic endowment 6is the harm caused by accidents In the language of the law the former work deals with crimes and intentional torts while this project relates to accidental negligent or reckless tortsEach year approximately 94000 Americans die and 19 million are injured as the result of accidental injuries which include personal injuries in the workplace motor vehicle crashes and disasters in the transportation industry2 The economic costs are estimated at 480 billion per year noneconomic costs exceed one trillion dollars3No estimate has been made of the proportion of these accidents that are the result at least in part of genetic factors However several genetic factors are known or suspected For example it is well known that genetic factors predispose certain individuals to develop disorders whose symptoms include accidentprone behaviors These include Alzheimers disease4 alcoholism5 epilepsy6 vision impairments7 and the movement disorders associated with Huntingtons disease8 In addition studies currently are underway at the National Institutes of Health on the relationship between noveltyseeking impulsivity and criminal behavior Similar inclinations toward risktaking could incline individuals toward behaviors that cause accidents It can also be expected that further genetic correlates with accidentcausing behavior will be discovered in the futureOne physiologic cause of accidents that is receiving considerable attention in the policy arena is sleep disorders Sleepiness is a causative factor in as many as 3 of all US motor vehicle accidents9 Accident victims receiving emergency room care are more likely to have sleep apnea than a control population odds ratio = 6310 Many sleep disorders are known or believed to be inherited Genes for the human disease ``narcolepsy a neurologic disorder of excessive daytime sleepiness and cataplexy known to cluster in families and in persons with specific inheritance of immune markers are very likely to be discovered in the near future Work is underway to locate genes responsible for other sleep disorders such as obstructive sleep apnea/hypopnea syndrome dissociated REM sleep restless legs syndrome and parasomnia all of which show patterns of inheritance11 Genetic testing for sleep disorders may be particularly important because unlike with alcohol or druginduced accidents there are no current physiologic measures for sleepiness in the immediacy of accidents such as automobile crashes12 Instead sleepiness is identified based on questionnaires and electrophysiological measures which are not conducive to the immediate prevention of accidents nor to the detection of those at risk Systems are under development to measure sleepiness in occupations such as commercial and noncommercial driving where the costs of a fallasleep accident are high13 These include brainwave monitors and devices that identify steering deviation and line drift This technology is not yet proven however and may be costly


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Other Papers In This Journal:

  1. Effects of resistance training on respiratory function in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis
  2. Art competition: Sleep and Breathing 2009
  3. Tailored behavioral medicine intervention for enhanced physical activity and healthy eating in patients with obstructive sleep apnea syndrome and overweight
  4. Age is associated with self-reported sleep bruxism, independently of tooth loss
  5. The effect of CPAP treatment on venous lactate and arterial blood gas among obstructive sleep apnea syndrome patients
  6. How common is sleep-disordered breathing in patients with idiopathic pulmonary fibrosis?
  7. Cephalometric calcified carotid artery atheromas in patients with obstructive sleep apnea
  8. Validation of blood pressure monitoring using pulse transit time in heart failure patients with Cheyne–Stokes respiration undergoing adaptive servoventilation therapy
  9. A systematic review of central sleep apnea in adult patients with chronic kidney disease
  10. The effect of weight loss on obstructive sleep apnea (OSA) severity and position dependence in the bariatric population
  11. The influence of obesity and obstructive sleep apnea on metabolic hormones
  12. Is obstructive sleep apnea syndrome in children season dependent?
  13. Hemostatic implications of endothelial cell apoptosis in obstructive sleep apnea
  14. Improvement in quality of life after adenotonsillectomy in a child with Prader Willi syndrome
  15. Elevated incidence of sleep apnoea in acromegaly—correlation to disease activity
  16. A promising concept of combination therapy for positional obstructive sleep apnea
  17. Continuous positive airway pressure intolerance associated with elevated nasal resistance is possible mechanism of complex sleep apnea syndrome
  18. Factors that influence CPAP adherence: an overview
  19. Respiratory regulation in narcolepsy
  20. Long-Term Results of Maxillomandibular Advancement Surgery
  21. Correlation between sleep parameters, physical activity and quality of life in somnolent moderate to severe obstructive sleep apnea adult patients
  22. Oral health in patients treated by positive airway pressure for obstructive sleep apnea: a population-based case–control study
  23. Left Ventricular Dysfunction, Pulmonary Hypertension, Obesity, and Sleep Apnea
  24. Correlation between retroglossal airway size and body mass index in OSA and non-OSA patients using cone beam CT imaging
  25. Reply to “Serum high-sensitivity C-reactive protein in patients with obstructive sleep apnea with special reference to metabolic syndrome” by Kawada (Letter to the Editor)
  26. Underdiagnosis of Sleep Apnea Syndrome in U.S. Communities
  27. Longitudinal comparison study of pressure relief (C-Flex™) vs. CPAP in OSA patients
  28. Sleep duration, obesity, and asthma, in Florida adolescents: analysis of data from the Florida Youth Risk Behavior Survey (2009–2013)
  29. Safety of ramelteon in individuals with mild to moderate obstructive sleep apnea
  30. CPAP therapy for patients with sleep apnea and type 2 diabetes mellitus improves control of blood pressure
  31. Zopiclone effects on breathing at sleep in stable chronic obstructive pulmonary disease
  32. Influence of gender on continuous positive airway pressure requirements in patients with obstructive sleep apnea syndrome
  33. Process and outcome for international reliability in sleep scoring
  34. Comorbidity modulates non invasive ventilation-induced changes in breath print of obstructive sleep apnea syndrome patients
  35. Variables affecting the change in systemic blood pressure in response to nasal CPAP in obstructive sleep apnea patients
  36. Seasonal trends in sleep-disordered breathing: evidence from Internet search engine query data

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