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Title of Journal: Sleep Breath

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Abbravation: Sleep and Breathing

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Springer Berlin Heidelberg

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DOI

10.1016/0022-2828(90)90855-v

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1522-1709

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A systematic review of central sleep apnea in adul

Authors: Gaurav Nigam Charu Pathak Muhammad Riaz
Publish Date: 2016/01/27
Volume: 20, Issue: 3, Pages: 957-964
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Abstract

Obstructive sleep apnea has been widely studied in patients with chronic renal insufficiency however only a limited number of studies have reviewed the association between central sleep apnea CSA and chronic kidney disease CKD The objectives of this systematic review were to assess the prevalence of CSA in and its association with CKD in adult patients and to determine if inclusion of the central hypopnea index affected the reported rates for the prevalence of CSA in CKDOf 188 articles searched 8 articles met our study inclusion criteria Of a cumulative total of 313 patients with CKD undergoing sleep study a total of 30 patients were diagnosed with central sleep apnea Three studies had patients with coexistent congestive heart failure six studies included some patients on dialysis and at least 3 studies included central hypopneas while calculating central sleep apnea indexThe aggregate point prevalence of CSA in CKD is 96  although the estimated range is highly variable between 0 and 75  Limited evidence suggested that even after adjustment for cardiovascular comorbidities CKD is independently associated with CSA It is unknown if patients on dialysis are at increased risk compared to patients without endstage renal disease Standardization of polysomnographic criteria used to define CSA and sleep disordered breathing SDB as well as inclusion of central hypopneas in the overall CSA index will limit the heterogeneity and allow better estimation of the prevalence of CSA in patients with CKDGN is the guarantor of the manuscript and takes full responsibility for the integrity of the presented data and the accuracy of the data analysis GN is the principal investigator of the study GN CP and MR contributed to the study concept and design data acquisition and analysis data interpretation drafting of the manuscript and approval of the final manuscriptAll authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest such as honoraria educational grants participation in speakers’ bureaus membership employment consultancies stock ownership or other equity interest and expert testimony or patentlicensing arrangements or nonfinancial interest such as personal or professional relationships affiliations knowledge or beliefs in the subject matter or materials discussed in this manuscript

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