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Title of Journal: Sleep Breath

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Abbravation: Sleep and Breathing

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Springer Berlin Heidelberg

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DOI

10.1007/s00467-015-3206-3

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ISSN

1522-1709

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CPAP therapy for patients with sleep apnea and typ

Authors: Jamie Chung Mei Lam Agnes Yuen Kwan Lai Terence Chi Chun Tam Michele MAE Ann Yuen Karen Siu Ling Lam Mary Sau Man Ip
Publish Date: 2016/11/05
Volume: 21, Issue: 2, Pages: 377-386
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Abstract

Obstructive sleep apnea OSA is highly associated with type 2 diabetes mellitus DM and treatment of OSA may have a positive impact on cardiometabolic profile This study investigates the effects of continuous positive airway pressure CPAP treatment on glycemic control and cardiometabolic parameters in patients with diabetesDiabetic patients who were newly diagnosed of OSA with an apnea hypopnea index AHI ≥15 and HbA1c ≥7 were randomly assigned to either CPAP treatment or no treatment control for 3 months Measurements included HbA1c blood pressure fasting glucose and lipids urinary albumin and peripheral arterial tonometry to assess endothelial functionSixtyfour patients 52 men were randomized with mean ±SD age of 550 ± 96 years body mass index of 299 ± 53 kg/m2 HbA1c of 81 ± 11 and AHI of 453 ± 232 events/h In the intentiontotreat analysis no significant change in HbA1c but reduction of systolic 10 mmHg −18 to −2 p  005 and diastolic 6 mmHg −11 to −1 p  005 blood pressures were found in the CPAP group compared to the control group Excluding those with medication changes or initiated dietary program during the study period and those who dropped out CPAP treatment decreased HbA1c intervention group n = 27 control group n = 26 by 04 −07 to −01 p = 0027In patients with type 2 DM and moderate to severe OSA 3 months of CPAP therapy did not decrease HbA1c but lowered systolic and diastolic blood pressures In view of a potentially limited effect size of CPAP treatment on glycemic control sample size estimation for future randomized controlled studies must make adequate allowance for influence from external factors of medications/diet and CPAP use

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