Authors: WeiTe Wu SaouHsing Liou
Publish Date: 2015/09/28
Volume: 20, Issue: 1, Pages: 385-385
Abstract
In our report we used the AHI as both a continuous or categorical variable to do sensitivity analysis of how inputs and parameters affect outputs The results showed that AHI as a continuous variable was significantly associated with hsCRP model 2 β = 0125 p = 0009 and also had a significant association with hsCRP model 2 β = 0533 p = 0005 for severe OSA as a categorical variable when compared to the nonOSA group after being adjusting for age smoking drinking and MetS status 1 Based on the American Academy of Sleep Medicine AASM consensus report the severity of OSA by classification of AHI is commonly used such as severe OSA AHI 30/h moderate OSA AHI 15–30/h persons at risk for OSA AHI 5–14/h and normal persons AHI 5/h 2 Therefore we believe that OSA classification can provide more detailed and useful information to readers Similarly the cutpoint of hsCRP as the value of 80th percentile or 90th percentile is also a sensitive analysis to confirm our resultsOur study shows that OSA was strongly associated with hsCRP and that the effect of OSA on CRP is independent of MetS Indeed results from this crosssectional study may not be interpreted as having a causal association of MetS in the pathway from OSA to elevated hsCRP However a previous a review article showed that OSA is thought possibly to lead to intermittent hypoxia increased systemic inflammation that is promoted by upregulation of NFκB leading to increased levels of TNF and possibly by activation of HIF1 as well as via increased levels of IL6 and CRP and thereby induce endothelial dysfunction 3 Besides we do not ignore the importance of obesity as a determinant of increased HsCRP Thus we concluded that CRP levels are elevated in OSA patients and that this probably reflects both obesity and intermittent hypoxia
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