The effect of CPAP treatment on venous lactate and

Authors: Ting Lin JieFeng Huang QiChang Lin GongPing Chen BiYing Wang JianMing Zhao JiaChao Qi

Publish Date: 2016/09/29

Volume: 21, Issue: 2, Pages: 303-309

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Abstract

The aim of this observational study was to investigate the influence of continuous positive airway pressure CPAP on arterial blood gas and venous lactate markers of tissue hypoxia among obstructive sleep apnea syndrome OSAS patients and determine the risk factor of serum lactate and hydrogen ion concentration PH in OSAS patientsOnehundred and nine patients with newly diagnosed OSAS were enrolled in the study All individuals were treated with CPAP for one night Venous lactate and arterial blood gas were gathered from all subjects in the morning at the end of polysomnography and the next morning after CPAP treatmentOf the 109 selected subjects the average lactate level was 223 ± 059 mmol/L and the mean PH PaO2 and PaCO2 were 7380 ± 023 8814 ± 1783 mmHg and 3870 ± 428 mmHg respectively Compared to baseline lactic acid significantly decreased 210 ± 050 mmol/L p = 003 while PH increased 7388 ± 027 p  005 after CPAP treatment In addition neck circumference and the polysomnographic parameters including apneahypopnea index oxygen desaturation index ODI mean oxygen saturation SpO2 and the percentage of sleep time with SpO2 90  TS90  positively correlated with lactate while age correlated negatively with lactate all p  005 Significantly positive associations were found between age neck circumference and PH furthermore a negative correlation was found between ODI and PH Finally after adjusting for confounding factors TS90  was the major contributing predictor for elevated lactate p  005 and age was a predictor for an increase in PH p  005The results indicated that CPAP treatment could reduce serum lactate and increase PH in OSAS patients and might alleviate acidbase balance disorders in OSAS Furthermore TS90  was a risk factor for elevated lactate and age was independently associated with PHAll authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest such as honoraria educational grants participation in speakers’ bureaus membership employment consultancies stock ownership or other equity interest and expert testimony or patentlicensing arrangements or nonfinancial interest such as personal or professional relationships affiliations knowledge or beliefs in the subject matter or materials discussed in this manuscriptAll procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standardsTing Lin contributed to the study design sequence data analysis and preparation of the manuscript JieFeng Huang contributed to the study design and preparation of the manuscript QiChang Lin contributed to the experimental design GongPing Chen performed the experiments BiYing Wang analyzed the data JianMing Zhao collected the data JiaChao Qi contributed to the preparation of the manuscript

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