Authors: Yuzuru Kuriyama Yoshiko Uchida Makoto Yaguchi Atsuhiro Iwabuchi Hiromi Serizawa Junko H Ohyashiki Kazuma Ohyashiki
Publish Date: 2001/08/16
Volume: 74, Issue: 2, Pages: 193-196
Abstract
We report 2 patients with follicular lymphoma FL which was accompanied by Waldenström’s macroglobulinemia WM One patient was a 65yearold woman and the other a 60yearold man Both patients showed a high level of circulating macroglobulin 46 g/dL and 36 g/dL respectively and bone marrow involvement of small lymphoid cells Moreover in each case the macroglobulinproducing component and the follicular component were determined to be of the same clone based on their identical lightchain restriction pattern and other factors However there was a difference in the histopathological characteristics of the macroglobulinproducing components of the 2 patients especially the cytoplasmic immunoglobulin IgM+ cell distribution in the biopsied lymph nodes Test results for the female patient showed intrafollicular proliferation of those cellsThe male patient’s test results showed that IgM+ cells were located in the narrow extrafollicular areas of the lymph nodes Our observations suggest that at least 2 different subtypes of FL may also be causative of a WM presentation
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