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Title of Journal: Int J Hematol

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Abbravation: International Journal of Hematology

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Springer Japan

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DOI

10.1016/0022-2860(86)80298-8

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1865-3774

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The Kinetics of Immune Reconstitution after Cord B

Authors: Hiroyasu Inoue Yukiharu Yasuda Kinya Hattori Takashi Shimizu Masae Matsumoto Miharu Yabe Hiromasa Yabe Fumiko Tsuchida Yumiko Tanaka Gaku Hosoi Masahiro Sako Shunichi Kato
Publish Date: 2003/05/01
Volume: 77, Issue: 4, Pages: 399-407
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Abstract

The present study compares immune reconstitution after allogeneic cord blood transplantation CBT and CD34+ stem cell transplantation CD34SCT with that after bone marrow transplantation BMT Eightyeight children who underwent CBT 20 patients BMT 58 and CD34SCT 10 were enrolled and lymphocytes and T B and natural killer—lymphocyte subsets were monitored for more than 5 years after transplantation CBT recipients showed significant increases in 1 total lymphocyte counts P 001 2 CD4+/CD8+ cell ratios P 01 3 CD4+ and CD4+CD45RA+ cells P 001 4 CD8+CD11b+ cells P 001 and 5 CD19+ and CD19+CD5+ cells P 0001 and marked decreases in the frequencies of CD8+ and CD8+CD11b cells P 0001 CD34SCT recipients showed lower lymphocyte counts in the first 6 months and an emergence of lymphocyte and CD4+CD45RA+ cells at approximately 9 months and 1 year Both CBT and CD34SCT recipients showed increased frequencies of CD56+ cells at 1 month CD34SCT versus BMT P 001 but decreased frequencies after 6 months CBT versus BMT P 001 Lymphoproliferative responses to exogenous interleukin 2 were constantly lower in CBT and CD34SCT recipients than in BMT recipientsThese results suggest that the delay in immune reconstitution after CBT in the early phase was mainly qualitative and related to the immaturity of cells whereas the delay in CD34SCT was mainly quantitative in the first several months Int J Hematol 200377399407

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