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Title of Journal: Int J Hematol

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Abbravation: International Journal of Hematology

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Springer Japan

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DOI

10.1002/pamm.200610211

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1865-3774

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Effect of Continuous Subcutaneous Administration o

Authors: Junko Tanaka Takaaki Miyake Tadashi Shimizu Toshio Wakayama Michihiro Tsumori Kunio Koshimura Yoshio Murakami Yuzuru Kato
Publish Date: 2002/06/01
Volume: 75, Issue: 5, Pages: 489-492
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Abstract

We investigated the effects of lowdose granulocyte colonystimulating factor GCSF on the mobilization of stem cells in 6 healthy subjects When GCSF was administered by continuous subcutaneous infusion at a rate of 72 μg/day for 5 days the numbers of white blood cells and granulocytes rapidly increased to maximal levels CD34+ cells were mobilized to the peripheral blood in 3 days and the maximal level was reached 4 or 5 days after the start of treatment We attempted to determine whether the levels of mobilized stem cells that we could obtain using this method would be sufficient for peripheral blood stem cell transplantation Two of the 6 subjects complained of mild bone pain 4 or 5 days after the start of treatment but the pain did not affect their daily activities Only 1 abnormal result for serum alkaline phosphatase was found in the laboratory data The present preliminary results have provided us with a framework for a prospective study comparing lowdose continuous infusion with conventional mobilization proceduresInt J Hematol 200275489–492

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