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Title of Journal: Int J Hematol

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Abbravation: International Journal of Hematology

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Springer Japan

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10.1007/s10692-009-9142-x

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1865-3774

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Differing impacts of pretransplant serum ferritin

Authors: Soichiro Sakamoto Hiroshi Kawabata Junya Kanda Tatsuki Uchiyama Chisaki Mizumoto Tadakazu Kondo Kouhei Yamashita Tatsuo Ichinohe Takayuki Ishikawa Norimitsu Kadowaki Akifumi TakaoriKondo
Publish Date: 2012/12/07
Volume: 97, Issue: 1, Pages: 109-116
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Abstract

Studies have suggested an association between pretransplant serum levels of ferritin and Creactive protein CRP and complications of allogeneic hematopoietic stem cell transplantation HSCT To evaluate the prognostic impact of these biomarkers on the development of acute and chronic graftversushost disease GVHD we retrospectively studied 211 patients who underwent allogeneic HSCT for hematologic diseases at our institution The cumulative incidence rate of chronic GVHD at 3 years was 407  In the multivariate analysis elevated CRP levels ≥2 mg/L were significantly associated with a high incidence of chronic GVHD whereas high ferritin levels ≥880 ng/mL showed a tendency though not statistically significant to association with a low incidence of chronic GVHD No significant association was observed between the pretransplant serum ferritin or CRP levels and the incidence of acute GVHD Multivariate analysis indicated that high pretransplant serum ferritin levels were significantly associated with increases in treatmentrelated mortality and relapse rates Overall an elevated pretransplant serum ferritin level but not an elevated serum CRP level is a strong risk factor for overall mortality hazard ratio 216 P = 0002 Our results also indicate that pretransplant serum CRP levels may be a useful biomarker for predicting the risk of chronic GVHDThe authors would like to thank Rie Goi and Mika Kobayashi for their expert data management and secretarial assistance and all the staff of our transplant team for their dedicated care of the patients and donors This work was supported in part by a grantinaid for scientific research from the Ministry of Education Culture Sports Science and Technology of Japan

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