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Title of Journal: Int J Hematol

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Abbravation: International Journal of Hematology

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Springer Japan

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DOI

10.1007/s11746-012-2028-8

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1865-3774

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Acute myeloid leukemia and colon carcinoma during

Authors: Kazutaka Ozeki Yoshihisa Morishita Sigeki Saito Koji Umemura Yohei Yamaguchi Shotaro Tatekawa Koichi Watamoto Akio Kohno Tsuyoshi Nogimori
Publish Date: 2013/09/24
Volume: 98, Issue: 5, Pages: 620-624
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Abstract

We describe the case of a 70yearold male with acromegaly who developed colon carcinoma and myelodysplastic syndrome MDS during the course of acromegaly MDS progressed to acute myeloid leukemia but was refractory to chemotherapy Acromegaly is a rare disorder caused by excessive amounts of growth hormone GH primarily secreted by pituitary adenomas Patients with acromegaly are more prone to develop various malignancies but there are few reports of hematological malignancies in such patients In the present case excessive endogenous GH and insulinlike growth factorI levels may have altered cell proliferation and thereby affected the oncogenesis and chemosensitivity of both malignancies

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