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Title of Journal: Int J Hematol

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Abbravation: International Journal of Hematology

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Springer Japan

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DOI

10.1007/bf00523448

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1865-3774

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Prevalence of Intravascolar Large BCell Lymphoma

Authors: Masafumi Ito Yonggoo Kim Jong Wcon Choi Hiroaki Ozawa Masahiko Fujino
Publish Date: 2003/02/01
Volume: 77, Issue: 2, Pages: 159-163
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Abstract

We used immunohistochemical analysis to investigate 146 bone marrow BM clot specimens from patients with fever of unknown origin FUO n = 124 or hemophagocytic syndrome HPS n = 22 Intravascular lymphoma IVL primarily involving BM was detected in 12 82 of the 146 patients Diagnosis was based on the presence of CD20+ and CD79a+ tumor cells confined within the lumina of sinuses and surrounded by CD34+ endothelial cells Of the 12 IVL cases 6 were CD5+ of these 6 CD5+ cases 5 were positive for vimentinThe finding of a considerably high prevalence of IVL tumor cells in BM from patients with FUO or HPS suggests that immunohistochemical examination of BM may be helpful in the diagnosis of IVL in these patients Vimentin coexpression in CD5+ IVL might be evidence of origin from a subset of prefollicular Bcells Int J Hematol

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