Authors: Haruhito Totani Shigeru Kusumoto Yasuhito Tanaka Nana Suzuki Shinya Hagiwara Shiori Kinoshita Etsuko Iio Asahi Ito Masaki Ri Takashi Ishida Hirokazu Komatsu Shinsuke Iida
Publish Date: 2016/06/02
Volume: 104, Issue: 3, Pages: 384-391
Abstract
Wisteria floribunda agglutininpositive human Mac2binding protein WFA+M2BP was developed recently as a predictive marker of progression to liver fibrosis and hepatocellular carcinoma HCC in patients seropositive for hepatitis C virus HCV We retrospectively analyzed 16 HCVseropositive patients who received systemic chemotherapy for hematologic malignancies to evaluate the usefulness of WFA+M2BP for predicting HCVrelated complications These were defined as the onset of significant liver damage LD with increased HCV RNA levels leading to interrupted or discontinued chemotherapy or the occurrence of HCC after chemotherapy Baseline WFA+M2BP levels were determined using preserved serum samples The median level of WFA+M2BP was 159 cutoff index COI value range 038–666 With a median followup of 623 days range 120–2404 LD and HCC were observed in three and two patients respectively Detectable HCV RNA and WFA+M2BP ≥20 COI at baseline were identified as risk factors for these HCVrelated complications P = 0034 and P = 0005 respectively The sensitivity specificity and positive and negative predictive values of the WFA+M2BP level cutoff point 20 COI for the occurrence of HCVrelated complications were 1000 818 714 and 1000 respectively WFA+M2BP may be a useful marker for the prediction of HCVrelated complications in HCVseropositive patients following systemic chemotherapy
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