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Title of Journal: Int J Hematol

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Abbravation: International Journal of Hematology

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Springer Japan

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DOI

10.1007/s00125-007-0659-3

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1865-3774

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Deregulated transcription factors in leukemia

Authors: Yutaka Shima Issay Kitabayashi
Publish Date: 2011/08/09
Volume: 94, Issue: 2, Pages: 134-141
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Abstract

Specific chromosomal translocations and other mutations associated with acute myeloblastic leukemia AML often involve transcription factors and transcriptional coactivators Such target genes include AML1 C/EBPα RARα MOZ p300/CBP and MLL all of which are important in the regulation of hematopoiesis The resultant fusion or mutant proteins deregulate the transcription of the affected genes and disrupt their essential role in hematopoiesis causing differentiation block and abnormal proliferation and/or survival This review focuses on such transcription factors and coactivators and describes their roles in leukemogenesis and hematopoiesis

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