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Title of Journal: Int J Hematol

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Abbravation: International Journal of Hematology

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Springer Japan

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DOI

10.1007/bf00457924

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1865-3774

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Clonality investigation of morphologically dysplas

Authors: Xiao Li Lingyun Wu Shaoxu Ying Chunkang Chang Quan Pu
Publish Date: 2008/02/07
Volume: 87, Issue: 2, Pages: 176-183
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Abstract

The aim of this paper was to investigate whether the morphological dysplastic cells in myelodysplastic syndromes MDS marrows derived from abnormal chromosomal clone Fluorescence in situ hybridization was used in combination with immunochemistry/immunomagnetic bead sorting to investigate the penetration of chromosomal abnormalities into dysplastic hematopoietic cells in MDS patients with documented chromosome abnormalities in the bone marrow at diagnosis Typical granulocyte dysplasia was defined as granulocytes with bilobed pseudo Pelger–Huet anomaly erythrocyte dysplasia as trinucleus or nuclear budding erythrocytes 21 patients were investigated respectively and megakaryocytes dysplasia as lymphocytic appearance megakaryocytes 14 patients were investigated When data were analyzed as a whole the mean percentage of clonal cells with typical dysplasis was always lower than clonal cell percentage in all nucleated cells no matter whether in granulocytes erythrocytes or megakaryocytes For each individual case the situation was the same with just few exceptions The chromosome ploidy of micromegakaryocytes was obviously reduced when compared to reported normal megakaryocytes Our research suggested that trilineage morphological dyshematopoiesis is secondum alteration not a specific feature imagery of the abnormal chromosomal clone in MDS

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