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Title of Journal: Int J Hematol

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Abbravation: International Journal of Hematology

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Springer Japan

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DOI

10.1007/bf01604134

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1865-3774

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Severe hepatitis associated with varicella zoster

Authors: Akinao Okamoto Akihiro Abe Masataka Okamoto Tsukane Kobayashi Tomohiko Terazawa Yoko Inaguma Masutaka Tokuda Masamitsu Yanada Satoko Morishima Tadaharu Kanie Yukiya Yamamoto Motohiro Tsuzuki Yoshiki Akatsuka Shuichi Mizuta Tetsushi Yoshikawa Nobuhiko Emi
Publish Date: 2012/08/18
Volume: 96, Issue: 4, Pages: 516-520
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Abstract

Severe disseminated varicella zoster virus VZV infection rarely occurs in patients who are not recipients of hematopoietic stem cell transplantation This report concerns severe disseminated VZV infection in a diffuse large B cell lymphoma DLBCL patient treated with rituximab cyclophosphamide doxorubicin vincristine and prednisolone RCHOP The patient was an 82yearold male with DLBCL who had a history of type II diabetes mellitus He incurred VZV infection with severe hepatitis and disseminated intravascular coagulopathy after three courses of RCHOP When the VZV infection occurred antiVZV IgG was not detected and lymphopenia was observed We initiated treatment with acyclovir immunoglobulin and thrombomodulin alpha and rescued this patient We suggest that the use of chemotherapy for immunesuppressed elderly lymphoma patients may involve the risk of severe VZV infection

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