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Title of Journal: Int J Hematol

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Abbravation: International Journal of Hematology

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Springer Japan

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DOI

10.1002/cber.19220550716

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1865-3774

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Safety and efficacy of the terminal complement inh

Authors: Yuzuru Kanakura Kazuma Ohyashiki Tsutomu Shichishima Shinichiro Okamoto Kiyoshi Ando Haruhiko Ninomiya Tatsuya Kawaguchi Shinji Nakao Hideki Nakakuma Junichi Nishimura Taroh Kinoshita Camille L Bedrosian Marye Ellen Valentine Gus Khursigara Keiya Ozawa Mitsuhiro Omine
Publish Date: 2011/01/12
Volume: 93, Issue: 1, Pages: 36-46
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Abstract

Paroxysmal nocturnal hemoglobinuria PNH is a progressive and lifethreatening disease characterized by complementmediated chronic hemolysis resulting in serious lifethreatening complications and early mortality Eculizumab a humanized antiC5 monoclonal antibody that inhibits terminal complement activation has been shown to reduce hemolysis in PNH patients The pivotal openlabel 12week phase II registration study AEGIS was designed to evaluate the efficacy and safety of eculizumab in Japanese patients with PNH This trial achieved its primary endpoint of reducing intravascular hemolysis with high statistical significance Twentyseven of the 29 patients responded to eculizumab treatment resulting in an 87 reduction in hemolysis P  00001 and subsequent improvement in anemia P = 00003 despite reduction in transfusion requirements P = 0006 Fatigue and dyspnea significantly improved within 1–2 weeks of eculizumab treatment and the improvement was independent of changes in hemoglobin Chronic kidney disease CKD was common 66 and eculizumab treatment improved CKD in 41 of patients at 12 weeks P  0001 Elevated thrombotic risk was evident in Japanese PNH patients and eculizumab treatment normalized ddimer levels in 45 of patients with elevated ddimers at baseline P  0001 The AEGIS results demonstrate that eculizumab is effective safe and well tolerated in Japanese patients with PNH

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