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Title of Journal: Int J Hematol

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Abbravation: International Journal of Hematology

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Springer Japan

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10.1016/0167-4838(82)90428-9

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1865-3774

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Reduceddose cyclophosphamide in combination with

Authors: Sumiko Kohashi Takehiko Mori Risa Hashida Jun Kato Masuho Saburi Taku Kikuchi Yuya Koda Takaaki Toyama Yusuke Yamane Satomi Yamanaka Shinichiro Okamoto
Publish Date: 2014/11/09
Volume: 101, Issue: 1, Pages: 102-105
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Abstract

We read with great interest the recent report by Ashizawa et al showing a favorable outcome of allogeneic hematopoietic stem cell transplantation HSCT for aplastic anemia by use of a conditioning regimen consisting of reduceddose cyclophosphamide CY total 100 mg/kg fludarabine and antithymocyte globulin ATG 1 Although the outcome seems favorable some issues remain to be solved with this regimen including mixed chimerism and lateonset cytopenia In addition the small number of cases has limited the impact of their conclusion Although there have been attempts to reduce the dose of CY in the conditioning regimen for aplastic anemia the optimal dose of CY has yet to be established 2 3 4 5 6 7 Based on a previous study by the same institute we also applied the same conditioning regimen for patients with aplastic anemia undergoing allogeneic HSCT 8 In the present report we present several of these cases which we believe further support and

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