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Title of Journal: Calcif Tissue Int

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Abbravation: Calcified Tissue International

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Springer-Verlag

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DOI

10.1002/chin.199118100

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1432-0827

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Congenital Lack of COX2 Affects Mechanical and

Authors: Q Chen J Y Rho Z Fan S J F Laulederkind R Raghow
Publish Date: 2003/07/24
Volume: 73, Issue: 4, Pages: 387-392
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Abstract

We compared the mechanical properties of bones from mice lacking either a functional cycloxygenase1 C57BL6/DBA COX1−/− n = 9 or COX2 C57BL6/DBA COX2−/− n = 9 gene and wild type mice C57BL6/DBA n = 10 Twentyeight right femora from 3monthold male mice were used to determine bulk structural and material properties of bone by threepoint bending Bone matrix properties were also measured by nanoindentation to access the changes in bulk mechanical properties due to changes in bone matrix or bone geometry The bulk material properties elastic modulus P 005 ultimate stress P 001 of COX2−/− bones were lower than those of wildtype mice whereas the bulk structural properties stiffness P 02 breaking force P 01 were similar to those of the wildtype mice COX2−/− mice had a longer moment of inertia but their cortical bones were thinner and contained many more intracortical pores compared with the bones of the other two groups Finally the bone matrix properties of COX1−/− mice COX2−/− mice and their heterozygous littermates were similar to those of C57BL6/DBA wildtype mice

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