Abnormal Bone Mechanical and Structural Properties

Authors: K Y Cheuk T Y Zhu F W P Yu V W Y Hung K M Lee L Qin J C Y Cheng T P Lam

Publish Date: 2015/06/23

Volume: 97, Issue: 4, Pages: 343-352

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Abstract

Previous studies found adolescent idiopathic scoliosis AIS is associated with low bone mineral density BMD and abnormal bone quality whilst the association between AIS and their bone strength is unknown From highresolution peripheral quantitative computed tomographygenerated images bone mechanical properties can be evaluated with finite element analysis FEA and trabecular rodplate configuration related to trabecular bone strength can be quantified by structure model index SMI This study aimed to compare trabecular configuration and bone mechanical properties between AIS and the controls 95 AIS girls aged 12–14 years and 97 age and gendermatched normal controls were recruited Bilateral femoral necks and nondominant distal radius were scanned by dualenergy Xray absorptiometry for areal BMD and HRpQCT for SMI and FEA respectively Subjects were further classified into osteopenic and nonosteopenic group based on their areal BMD Bone mechanical properties stiffness failure load and apparent modulus were calculated using FEA Linear regression model was used for controlling age physical activity and calcium intake AIS was associated with lower failure load and apparent modulus after adjusting for age whereas AIS was associated with lower apparent modulus after adjusting for all confounders Osteopenic AIS was associated with more rodlike trabeculae when compared with nonosteopenic AIS whereas no difference was detected between osteopenic and nonosteopenic controls This might be the result of abnormal regulation and modulation of bone metabolism and bone modelling and remodelling in AIS which will warrant future studies with a longitudinal design to determine the significance of microarchitectural abnormalities in AISAll procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards

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