Authors: J M Liu H Y Zhao G Ning Y J Zhao Y Chen Zh Zhang L H Sun MY Xu J L Chen
Publish Date: 2004/10/07
Volume: 76, Issue: 1, Pages: 1-6
Abstract
The correlations between the serum levels of OPG RANKL with age menopause bone markers and bone mineral densities BMDs at the lumbar spine and proximal femur were studied in 504 pre and postmenopausal Chinese women aged 20–75 years We found that age was positively and negatively correlated with serum concentrations of OPG r = 0442 P 0001 and RANKL r = −0263 P 0001 respectively Compared with premenopausal women postmenopausal women showed higher serum OPG levels 1076 ± 30 vs 720 ± 18 pg/ml P 0001 lower serum RANKL concentrations 47 ± 04 vs 58 ± 03 pg/ml P 0001 and RANKL/OPG ratios 0045 ± 0 004 vs 0099 ± 0008 P 0001 Neither serum levels of OPG nor RANKL or RANKL/OPG ratio correlated with BMDs after adjustment of age and menopause They also showed no differences among normal osteopenic and osteoporotic postmenopausal women Serum levels of OPG were positively correlated with urinary excretion of NTx r = 01453 P = 0006 Serum levels of RANKL r = −01928 P 0001 and RANKL/OPG ratio r = −01303 P = 0013 were inversely correlated with serum concentrations of OC In multiple regression analysis up to 20 variance R2 = 0106–0224 of the OPGRANKL system in peripheral circulation can be explained by age menopause and bone markersThese results suggest that although serum OPG and RANKL concentrations were unrelated with BMDs the age– and menopause– dependent changes of serum OPG and RANKL might be a protective mechanism against the accelerated bone loss in postmenopausal womenThis study was supported by the Key Instructor Sponsor Program Ministry of Education China OOTPJS111 Medical Star Program Shanghai Health Bureau Young and Middleage Outstanding Instructor Training Program Shanghai Second Medical University and partly from Key Discipline Construction Fee Shanghai Education Committee
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