Physical Activity and Bone Turnover Markers A Cro

Authors: Silvano Adami Davide Gatti Ombretta Viapiana Carmelo Erio Fiore Ranuccio Nuti Giovanni Luisetto Marco Ponte Maurizio Rossini On Behalf of the BONTURNO Study Group

Publish Date: 2008/10/24

Volume: 83, Issue: 6, Pages: 388-392

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Abstract

Strenuous physical activity in young individuals has an important effect on both bone mass and bone turnover but the effect of moderate physical activity in adults remains uncertain In a large cohort N = 530 of healthy premenopausal women bone formation markers osteocalcin and Nterminal propeptide of type 1 procollagen P1NP but not serum Ctelopeptide of type 1 collagen sCTX were found to be significantly associated with the level of physical activity and this association remained significant after adjusting the data ANCOVA by age and body mass index Mean spine and hip bone mineral density BMD values were positively associated with physical activity but this was statistically significant P = 0050 only for adjusted values of spine BMD Twentyfour healthy sedentary premenopausal women subscribing to participate in a community exercise program lasting a month and 18 agematched controls were included in the longitudinal study Serum osteocalcin and P1NP but not sCTX rose significantly by ca 25 only in the active group after a month of exercise The changes in the two bone formation markers remained statistically significant for values adjusted for body weight which fell significantly in the exercise group In conclusion both the crosssectional and the longitudinal parts of our study demonstrate that even minor changes in physical activity are associated with a clear effect on bone formation markersSilvano Adami has served as a consultant for Abiogen Roche Merck Novartis and Amgen Ranuccio Nuti has served as a consultant for Procter Gamble and Roche Carmelo Erio Fiore and Ombretta DiMunno have received honoraria as a consultant for Merck ItalyParticipants were as follows in alphabetical order Silvano Adami Verona Maurizio Bevilacqua Milano Gerolamo Bianchi Genova Ottavio Bosello Verona Francesco Cantatore Foggia Ombretta Di Munno Pisa Erio Fiore Catania Bruno Frediani Siena Nicola Frisina Catania Giorgio Gandolini Milano Sandro Giannini Padova Vincenzo Lo Cascio Verona Giovanni Luisetto Padova Claudio Marcocci Pisa Salvatore Minisola Roma Maurizio Muratore Lecce Ranuccio Nuti Siena Sergio Ortolani Milano Gian Battista Rini Palermo Maurizio Rossini Verona and Fabio Massimo Ulivieri Milano

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