Variation in the Emphasis Type="Italic"BMP2/Emp

Authors: Fiona E McGuigan Emma Larzenius Mattias Callreus Paul Gerdhem Holger Luthman Kristina Åkesson

Publish Date: 2007/08/29

Volume: 81, Issue: 4, Pages: 254-262

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Abstract

Bone morphogenetic protein2 BMP2 plays a key role in bone formation and maintenance Studies of polymorphisms within the gene in relation to bone mineral density BMD and fracture have been inconsistent Our aim was to investigate associations between polymorphisms in the BMP2 gene and bone mass fracture and quantitative ultrasound QUS measures at different stages of skeletal development Study subjects were participants of two populationbased cohorts of Swedish women the PEAK25 cohort of young adult women aged 25 years n = 993 and the OPRA cohort of elderly women aged 75 years n = 1001 We analyzed four singlenucleotide polymorphisms SNPs across the BMP2 gene including the Ser37Ala SNP previously identified in relation to BMD QUS of the calcaneus and in the elderly women fracture BMP2 gene variations were associated with QUS of bone independent of BMD but only in the young women Even after adjusting for confounding factors SNP rs235754 in the 3′ region of the gene was significantly associated with the ultrasound parameters speed of sound P = 0003 and stiffness P = 0002 The 5′ SNP rs235710 showed trends for QUS parameters P = 002–007 No association with BMP2 SNPs was observed in either cohort for either BMD or fracture While further more extensive genotyping across the gene is recommended as we may not have captured all information our preliminary data suggest that variation in BMP2 may play a previously unidentified role in aspects of bone quality which may be age and sitedependentSupport for the study was received from the Swedish Research Council Greta and Johan Kock Foundation A Påhlsson Foundation A Osterlund Foundation Swedish Center for Sports Medicine Research Malmö University Hospital Research Foundation and Swedish Medical Society We thank Dr Alison Stewart University of Aberdeen for advice on QUS Lisa Jansson for genotyping support the research nurses at the Clinical and Molecular Osteoporosis Research Unit and all the women who kindly participated in the study

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