Authors: D Sudhaker Rao Nayana Parikh Saroj Palnitkar Shijing Qiu
Publish Date: 2013/07/11
Volume: 93, Issue: 3, Pages: 288-295
Abstract
Little is known about the effect of endogenous parathyroid hormone PTH on the skeleton in postmenopausal women without hyperparathyroidism In this study the effects of PTH on bone were investigated in iliac crest biopsies obtained from 37 healthy white postmenopausal women aged 50–73 years The results showed that neither cancellous nor cortical bone structure changed with serum PTH levels In cancellous bone bone formation wall thickness osteoid surface osteoblast surface mineralizing surface and mineral apposition rate and turnover bone formation rate at the surface volume levels and activation frequency variables increased with increasing serum PTH levels all p 005 in univariate analysis Multiple linear regressions adjusted for serum 25OHD calcium alkaline phosphatase age and BMI showed that serum PTH level was independently associated with wall thickness osteoid surface osteoblast surface mineralizing surface and bone formation rate all p 005 In cortical bone no histomorphometric variable was correlated with PTH levels On the endosteal surface some of the bone formation osteoid surface osteoblast surface mineralizing surface and turnover bone formation rate at the bone surface levels and activation frequency variables were positively correlated with PTH levels all p 005 None of these variables could be independently predicted by PTH status We conclude that in healthy postmenopausal women endogenous PTH has a positive effect on bone formation on the cancellous surface The effects of PTH on the endosteal surface are probably confounded by other factors
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