Determinants of Bone Turnover Markers in Healthy P

Authors: Silvano Adami Gerolamo Bianchi Maria Luisa Brandi Sandro Giannini Sergio Ortolani Ombretta DiMunno Bruno Frediani Maurizio Rossini On behalf of the BONTURNO study group

Publish Date: 2008/05/10

Volume: 82, Issue: 5, Pages: 341-347

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Abstract

Bone turnover markers BTMs are widely used for the management of osteoporosis and the premenopausal reference range is the target value for the treatment of postmenopausal osteoporosis with antiresorbing agents Three serum BTMs serum Ctelopeptide of type I collagen CTX osteocalcin OC and Nterminal propeptide of type I procollagen P1NP serum calcium creatinine phosphate magnesium and folliclestimulating hormone FSH were measured in 638 healthy premenopausal women aged 20–50 years In 83 women on the contraceptive pill CP the levels of the three BTMs adjusted for all confounding factors were 14–26 lower P  0005 than in nonCP users In 18 women considered perimenopausal for serum FSH levels 30 IU/mL despite having regular menses BTM levels were significantly higher than in agematched women This group of subjects and the women on the CP were excluded from further analysis The three BTMs significantly decreased with advancing age and were negatively and independently correlated with body mass index P  0001 and serum phosphate In conclusion we confirm that CP use is associated with significantly lower BTM values An increase in BTM concentrations can be observed in perimenopausal women ie women with normal menses but FSH levels 30 IU/mL BTMs decrease substantially with advancing age and this appears to be associated with changes in body weight and serum phosphate New normative ranges for serum OC CTX and P1NP were identified and our findings in general impose a redefinition of the criteria for establishing the normal ranges for BTMsMaurizio Bevilacqua Milano Gerolamo Bianchi Genova Ottavio Bosello Verona Francesco Cantatore Foggia Ombretta Di Munno Pisa Erio Fiore Catania Bruno Frediani Siena Nicola Frisina Catania Giorgio Gandolini Milano Sandro Giannini Padova Vincenzo Lo Cascio Verona Giovanni Luisetto Padova Claudio Marcocci Pisa Salvatore Minisola Roma Maurizio Muratore Lecce Ranuccio Nuti Siena Sergio Ortolani Milano Gian Battista Rini Palermo Maurizio Rossini Verona Fabio Massimo Ulivieri Milano

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