Factors Associated with the Serum Myostatin Level

Authors: Shunsuke Yamada Kazuhiko Tsuruya Hisako Yoshida Masanori Tokumoto Kenji Ueki Hiroaki Ooboshi Takanari Kitazono

Publish Date: 2016/02/19

Volume: 99, Issue: 1, Pages: 13-22

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Abstract

Myostatin is a member of the transforming growth factorβ family which regulates synthesis and degradation of skeletal muscle proteins and is associated with the development of sarcopenia It is upregulated in the skeletal muscle of chronic kidney disease patients and is considered to be involved in the development of uremic sarcopenia However serum myostatin levels have rarely been determined and the relationship between serum myostatin levels with clinical and metabolic factors remains unknown This crosssectional study investigated the association between serum myostatin level and clinical factors in 69 outpatients undergoing peritoneal dialysis Serum myostatin level was determined by commercially available enzymelinked immunosorbent assay ELISA Univariable and multivariable analysis were conducted to determine factors associated with serum myostatin levels The factors included age sex diabetes mellitus dialysis history body mass index residual kidney function peritoneal dialysate volume serum biochemistries and the use of vitamin D receptor activators VDRAs Mean serum myostatin level was 759 ± 337 ng/mL There was no association between serum myostatin level and residual kidney function Serum myostatin levels were significantly and positively associated with lean body mass measured by the creatinine kinetic method and negatively associated with the use of VDRAs after adjustment for potential confounding factors Our study indicated that serum myostatin levels are associated with skeletal muscle mass and are lower in patients treated with VDRAs Further studies are necessary to determine the significance of measuring serum myostatin level in patients undergoing peritoneal dialysisAll procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards

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