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Title of Journal: World J Urol

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Abbravation: World Journal of Urology

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Springer-Verlag

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10.1006/rtim.1996.0039

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1433-8726

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Androgens and prostate cancer

Authors: Alan I So Antonio HurtadoColl Martin E Gleave
Publish Date: 2003/10/29
Volume: 21, Issue: 5, Pages: 325-337
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Abstract

Over 60 years ago Huggins and Hodges demonstrated the importance of androgens and prostate cancer Since then significant research has revealed that this relationship is multifaceted and is interwoven with different signaling cascades and protein coactivators The complex interrelationship between hormone and cancer is best exemplified by the recurrence and progression of prostate cancer after hormonal therapy to a lethally resistant phenotype despite initially encouraging therapeutic responses If we are to significantly improve survival with novel therapies further understanding of the emergence of this resistant phenotype is essential The purpose of this article is to review the mechanisms of androgen action and its relation to hormonal therapy and mechanisms of hormonal resistance

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  2. Treatment of pediatric urolithiasis: how small is “small enough”?
  3. The effect of a cyclic uniaxial strain on urinary bladder cells
  4. The value of the preoperative 1-h pad test with pessary insertion for predicting the need for a mid-urethral sling following pelvic prolapse surgery: a cohort study
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  12. Influence of age on false positive rates of urine-based tumor markers
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  14. Changing concepts in the surgery of renal cell carcinoma
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  16. Reduction in incidence of lymphocele following extraperitoneal radical prostatectomy and pelvic lymph node dissection by bilateral peritoneal fenestration
  17. Should inclusion criteria for active surveillance for low-risk prostate cancer be more stringent? From an interim analysis of PRIAS-JAPAN
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