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Title of Journal: World J Urol

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Abbravation: World Journal of Urology

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Springer-Verlag

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10.1007/bf00141061

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1433-8726

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Loss of galectin3 expression correlates with clea

Authors: Axel S Merseburger Mario W Kramer Jörg Hennenlotter Jürgen Serth Stephan Kruck Alfredo Gracia Arnulf Stenzl Markus A Kuczyk
Publish Date: 2008/07/02
Volume: 26, Issue: 6, Pages: 637-
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Abstract

Galectin3 is a member of the glycoprotein family actively involved in various biological interactions including cell growth cell adhesion cell differentiation and apoptosis The aim of this study was to analyze the expression of galectin3 in clear cell renal carcinoma and to assess its prognostic significanceThe expression of galectin3 was analyzed by immunohistochemistry in 149 clear cell renal carcinomas The levels were correlated to established clinical parameters such as nuclear grade pathological stage lymph node distant metastasis and patients’ survivalIn normal kidney tissue the expression of galectin3 was found to be uniformly present in the tubular epithelial cells A decrease of antigen expression levels were significantly associated with higher Tstages P  002 unfavourable longterm prognosis in univariate Kaplan–Meier P  0007 and multivariate Cox proportional hazard analyses P  004 Univariate analysis could demonstrate an association with tumorspecific death with decreased galectin3 expression whereas multivariate analysis failed to prove the aforementioned observationThe immunohistochemical experiments have been performed in the laboratory facilities of Dr Vinata B Lokeshwar University of Miami Miller School of Medicine We greatly thank her for providing the antibody for galectin3 and continuous support and scientific discussion throughout the course of this work

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