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Title of Journal: World J Urol

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Abbravation: World Journal of Urology

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Springer Berlin Heidelberg

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DOI

10.1002/zaac.19774330119

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1433-8726

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Prognostic role of decreased Ecadherin expression

Authors: Ricardo L Favaretto Atessa Bahadori Romain Mathieu Andrea Haitel Bernhard Grubmüller Vitaly Margulis Jose A Karam Morgan Rouprêt Christian Seitz Pierre I Karakiewicz Isabela W Cunha Stenio C Zequi Christopher G Wood Alon Z Weizer Jay D Raman Mesut Remzi Nathalie RiouxLeclercq Solene JacquetKammerer Karim Bensalah Yair Lotan Alexander Bachmann Michael Rink Alberto Briganti Shahrokh F Shariat
Publish Date: 2016/04/29
Volume: 35, Issue: 1, Pages: 113-120
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Abstract

Decreased Ecadherin expression was observed in 353 patients 521  and was associated with advanced pathological stage P  0001 higher grade P  0001 lymph node metastasis P = 0006 lymphovascular invasion P  0001 concomitant carcinoma in situ P  0001 multifocality P = 0004 tumor necrosis P = 0020 and sessile architecture P  0001 Within a median followup of 30 months interquartile range 15–57 171 patients 254  experienced disease recurrence and 150 219  died from UTUC In univariable analyses decreased Ecadherin expression was significantly associated with worse recurrencefree survival P  0001 and cancerspecific survival CSS P = 0006 however in multivariable analyses it was not P = 074 and 084 respectively The lack of independent prognostic value of Ecadherin remained true in all subgroup analysesIn UTUC patients treated with RNU decreased Ecadherin expression is associated with features of biologically and clinically aggressive disease and worse outcome in univariable but not multivariable analyses If Ecadherin’s association with factors of advanced disease is confirmed on UTUC biopsy specimens it could be used to help in the clinical decisionmaking regarding kidneysparing approaches and/or neoadjuvant chemotherapy

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