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Title of Journal: World J Urol

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Abbravation: World Journal of Urology

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Springer Berlin Heidelberg

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DOI

10.1002/bate.201290015

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1433-8726

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Should inclusion criteria for active surveillance

Authors: Mikio Sugimoto Hiromi Hirama Akito Yamaguchi Hirofumi Koga Katsuyoshi Hashine Iku Ninomiya Nobuo Shinohara Satoru Maruyama Shin Egawa Hiroshi Sasaki Yoshiyuki Kakehi The PRIASJAPAN study group
Publish Date: 2014/11/27
Volume: 33, Issue: 7, Pages: 981-987
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Abstract

The inclusion criteria for the PRIAS study are as follows clinical stage T1c/T2 PSA ≤ 10 ng/ml PSA density PSAD  02 ng/ml per milliliter one or two positive biopsy cores and Gleason score GS ≤ 6 at initial diagnostic biopsy Baseline clinical characteristics and prostatespecific antigen doubling time PSADT at the time of reBx were analyzed via multivariate logistic regression with respect to reclassification and ‘no cancer’ status on the 1year reBxA total of 386 patients were enrolled in PRIASJAPAN by the end of 2013 Of these 216 underwent reBx at 1 year A total of 73 patients 338  were reclassified whereas 74 343  had no cancer Older age a higher PSAD a higher positive core rate and a shorter PSADT were significant predictors of reclassification The positive core rate was the predictor common to reclassification no cancer and high GS upon reBxAn interim analysis of a Japanese AS cohort participating in PRIAS revealed that the positive core rate was strongly associated with reclassification at the 1year reBx However although amendment of the PRIAS inclusion criteria to incorporate a positive core might reduce any concern about underestimation this would also reduce the number of patients undergoing ASWe thank Dr Tomonori Habuchi Dr Takamitsu Inoue Dr Tadashi Matsuda Dr Hidefumi Kinoshita Dr Seiji Naito Dr Akira Yokomizo Dr Osamu Ogawa Dr Tomomi Kamba Dr Akito Terai Dr Kazuhiro Suzuki Dr Kazuto Ito Dr Yasuo Kitamura Dr Toshihiro Saito Dr Taiji Tsukamoto Dr Naoya Masumori Dr Hiroshi Kitamura Dr Tomohiko Ichikawa Dr Shinichi Sakamoto Dr Toshiro Terachi Dr Takeshi Nomoto Dr Koichiro Akakura Dr Yoshiko Maeda Dr Yukio Honma Dr Hiroshi Fukuhara Dr Hiroyoshi Suzuki Dr Naoto Kamiya Dr Yoichi Arai Dr Koji Mitsuzuka Dr Hiroomi Kanayama Dr Tomoharu Fukumori Dr Hideki Sakai Dr Tsukasa Igawa Dr Seiichiro Ozono Dr Takayuki Sugiyama Dr Akio Matsubara Dr Jun Teishima Dr Toshiyuki Kamoto Dr Hiromasa Tsukino Dr Yoshihiko Tomita Dr Hisashi Kawazoe Dr Hideyasu Matsuyama Dr Hiroaki Matsumoto Dr Seiichi Saito Dr Takuma Oshiro Dr Isao Hara and Dr Takeshi Inagaki for their great contribution to this study The authors thank all contributions for PRIASJAPAN


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