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Title of Journal: World J Urol

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Abbravation: World Journal of Urology

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Springer Berlin Heidelberg

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1433-8726

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OnabotulinumtoxinA intradetrusorial injections imp

Authors: Antonella Giannantoni Silvia Proietti Guido Giusti Marilena Gubbiotti Enrico Millefiorini Elisabetta Costantini Alfredo Berardelli Antonella Conte
Publish Date: 2015/05/13
Volume: 33, Issue: 12, Pages: 2095-2101
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Abstract

We enrolled 31 MS female patients with symptoms of overactive bladder and detrusor overactivity All patients underwent urodynamics and were administered 3day voiding diary Incontinence Quality of Life IQoL questionnaire Female Sexual Function Index FSFI questionnaire Hamilton Anxiety Rating Scale HAMA and Hamilton Depression Rating Scale HAMD before and 3 months after Onabot/A intravesical injectionOnabot/A injection significantly improved urinary symptoms as shown by the 3day voiding diary IQoL questionnaire and the urodynamic variables In addition it also significantly improved sexual functioning in continent patients and psychological status as demonstrated by the increase in FSFI HAMA and HAMD scoresThe Onabot/Ainduced positive effect on sexual dysfunction in our MS patients is likely due to an indirect effect exerted by the overall urological clinical improvement on sexual function at both the psychological and emotional levels The positive effect exerted by Onabot/A on the anxiety and depression scale also suggests that urinary symptoms have a negative impact on the psychological status of the patients

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