Authors: M Horstmann T Todenhöfer J Hennenlotter S Aufderklamm J Mischinger U Kuehs G Gakis A Stenzl C Schwentner
Publish Date: 2012/07/18
Volume: 31, Issue: 4, Pages: 935-940
Abstract
Urinary cytology Cyt UroVysion FISH ImmunoCyt uCyt+ and NMP22 were determined in 1554 patients suspicious for UC of the bladder before cystoscopy and in case of cancer detection before TURB Additionally upper urinary tract imaging was performed Maker sensitivity specificity and FPRs were evaluated in the entire cohort and in subgroups divided by age into 50 ≥50–70 and ≥70 years Contingency tables and the Cochrane Armitage tests were used for statistical comparisonsUC was found in 377 and no UC in 1177 75 patients A total of 336 patients were diagnosed with UC of the bladder and 41 with UC of the upper urinary tract Overall sensitivity and specificity for Cyt were 82 and 82 for FISH 73 and 79 and for uCyt+ 79 and 75 respectively For NMP22 regardless of the exclusion criteria they were 72 and 34 and after exclusion of urinary tract infection UTI or prior to manipulation 46 and 86 respectively Significantly higher FPRs were found with increasing age for Cyt p = 0001 a trend to higher FPRs for uCyt+ p = 011 and almost no difference for FISH p = 063 For NMP22 differences became significant after exclusion of patients with UTI or prior manipulation p = 002
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