Authors: Vincenzo Ficarra G Novara R BoscoloBerto W Artibani M W Kattan
Publish Date: 2008/06/17
Volume: 27, Issue: 2, Pages: 155-
Abstract
Most of the authors select patients for early inguinal lymphadenectomy according to the pathologic extension of the primary tumor and its histologic grade as recommended by the EAU Guidelines and the Solsona risk groups Although the Solsona risk groups performed slightly better both risk groups had low predictive accuracy A nomogram including eight clinical and pathologic variables tumor thickness microscopic growth pattern Broder’s grade presence of vascular or lymphatic embolization infiltrations of the corpora cavernosa corpus spongiosum or urethra and the clinical stage of groin lymph nodes was developed to estimate the risk of lymph node involvement at followup Two nomograms are currently available able to estimate the 5year cancerspecific survival probabilities of the patients The first nomogram included the clinical lymph node stage and the same pathological variables of the primary tumor at penectomy while the pathological stage of the lymph nodes replaced the clinical one in the second model All the 3 nomograms had good prognostic accuracyBoth the Solsona and EAU risk group assessment had low prognostic accuracy although the Solsona risk groups performed slightly better The nomograms designed to predict the risk of lymph node metastases showed and cancerspecific survival had good prognostic accuracy but their external validation is still lacking
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